RegulonDB RegulonDB 10.9: Regulon Form
   
   


CRP,GlrR,NtrC,RcsB regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
RcsB Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional activator RcsB, RcsB response regulator
Gene name(s): rcsB
Functional conformation(s): RcsB-phosphorylated , RcsB
Coregulator(s): AdiY, ArcA, CRP, CadC, CpxR, EvgA, FNR, Fis, FliZ, GadE, GadE-RcsB, GadW, GadX, GlrR, H-NS, LeuO, LexA, Lrp, MarA, NagC, NarL, NarP, NhaR, NtrC, OmpR, PhoB, PhoP, RcsB, RcsB-BglJ, Rob, SdiA, StpA, TorR, UvrY, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GlrR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional activator GlrR, GlrR response regulator, QseF, YfhA
Gene name(s): glrR
Functional conformation(s): GlrR-phosphorylated , GlrR
Coregulator(s): CRP, GlrR, IHF, NtrC, RcsB
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NtrC Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator NtrC, GlnG, GlnT, NtrC response regulator
Gene name(s): glnG
Functional conformation(s): NtrC-phosphorylated
Coregulator(s): ArcA, ArgR, CRP, CysB, FNR, Fis, Fur, GadX, GlrR, IHF, Nac, NtrC, PhoP, RcsB, RutR, ppGpp

REGULATION EXERTED BY CRP,GlrR,NtrC,RcsB Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator GlrR activator NtrC activator RcsB activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator rpoEp2b rseC , rseB , rseA , rpoE , rseD 2710354 2710371 -23.0 tagcatcatgTTGTGCGGATAAACACCTgctattttaa   [1]
RcsB-phosphorylated activator rpoEp2b rseC , rseB , rseA , rpoE , rseD 2710385 2710398 -52.5 taatttactaAACATGGTTTGGTCAgcatagcatc   [1]
GlrR-phosphorylated activator rpoEp2b rseC , rseB , rseA , rpoE , rseD 2710420 2710440 -90.5 cgtcacatgaATGTTCAGGGAGAGTATTCATtttctttgtt   [1]
GlrR-phosphorylated activator rpoEp2b rseC , rseB , rseA , rpoE , rseD 2710396 2710413 -65.5 ttcattttctTTGTTTAATTTACTAAACAtggtttggtc   [1]
GlrR-phosphorylated activator rpoEp2b rseC , rseB , rseA , rpoE , rseD 2710357 2710374 -26.5 agcatagcatCATGTTGTGCGGATAAACAcctgctattt   [1]
NtrC-phosphorylated activator rpoEp2b rseC , rseB , rseA , rpoE , rseD 2710364 2710382 -33.5 tttggtcagcATAGCATCATGTTGTGCGGataaacacct   [1]
CRP-cAMP activator rseDp rseC , rseB , rseA , rpoE , rseD 2710354 2710371 -23.0 tagcatcatgTTGTGCGGATAAACACCTgctattttaa   [1]
GlrR-phosphorylated activator rseDp rseC , rseB , rseA , rpoE , rseD 2710357 2710374 -26.5 agcatagcatCATGTTGTGCGGATAAACAcctgctattt   [1]
RcsB-phosphorylated activator rseDp rseC , rseB , rseA , rpoE , rseD 2710385 2710398 -52.5 taatttactaAACATGGTTTGGTCAgcatagcatc   [1]
NtrC-phosphorylated activator rseDp rseC , rseB , rseA , rpoE , rseD 2710364 2710382 -33.5 tttggtcagcATAGCATCATGTTGTGCGGataaacacct   [1]
GlrR-phosphorylated activator rseDp rseC , rseB , rseA , rpoE , rseD 2710396 2710413 -65.5 ttcattttctTTGTTTAATTTACTAAACAtggtttggtc   [1]
GlrR-phosphorylated activator rseDp rseC , rseB , rseA , rpoE , rseD 2710420 2710440 -90.5 cgtcacatgaATGTTCAGGGAGAGTATTCATtttctttgtt   [1]

Reference(s): [1] Klein G., et al., 2016



Reference(s)    

 [1] Klein G., Stupak A., Biernacka D., Wojtkiewicz P., Lindner B., Raina S., 2016, Multiple Transcriptional Factors Regulate Transcription of the rpoE Gene in Escherichia coli under Different Growth Conditions and When the Lipopolysaccharide Biosynthesis Is Defective., J Biol Chem 291(44):22999-23019


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