RegulonDB RegulonDB 10.9: Regulon Form
   
   


Cra,DksA,SgrR,ppGpp regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Cra Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator Cra, FruC, FruR, Shl
Gene name(s): cra
Functional conformation(s): Cra , Cra-β-D-fructofuranose 1-phosphate , Cra-β-D-fructose 1,6-bisphosphate , Cra-;-D-fructose 1,6-bisphosphate
Coregulator(s): AcrR, ArcA, BasR, BetI, BolA, BtsR, CRP, CpxR, Cra, CsgD, CusR, DcuR, DksA, FNR, Fis, FliZ, Fur, GadE, GlcC, GntR, H-NS, HprR, IHF, IclR, KdgR, Lrp, MarA, MarR, Mlc, MlrA, MqsA, NagC, NarL, NarP, OmpR, PdhR, PrpR, RcdA, RcsAB, Rob, RstA, SgrR, SoxS, TyrR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
SgrR      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator SgrR, YabN
Gene name(s): sgrR
Functional conformation(s): SgrR
Coregulator(s): Cra, DksA, SgrR, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY Cra,DksA,SgrR,ppGpp Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
Cra repressor DksA activation SgrR activator ppGpp activation    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
Cra repressor sgrSp2 sgrS , sgrT , setA 77026 77043 -332.5 tgcaccagttGATCGATACGATCCTGCTCcagcaggtct   [1]
SgrR activator sgrSp2 sgrS , sgrT , setA 77297 77330 -53.5 gagcagatggCATAAAAGGGGAACTCCTGTGCAAAAGACAGCAATtttattttcc   [2]
[3]
[4]

Reference(s): [1] Shimada T., et al., 2011
[2] Sun Y., et al., 2011
[3] Vanderpool CK., et al., 2004
[4] Vanderpool CK., et al., 2007



Reference(s)    

 [1] Shimada T., Yamamoto K., Ishihama A., 2011, Novel members of the Cra regulon involved in carbon metabolism in Escherichia coli., J Bacteriol 193(3):649-59

 [2] Sun Y., Vanderpool CK., 2011, Regulation and function of Escherichia coli sugar efflux transporter A (SetA) during glucose-phosphate stress., J Bacteriol 193(1):143-53

 [3] Vanderpool CK., Gottesman S., 2004, Involvement of a novel transcriptional activator and small RNA in post-transcriptional regulation of the glucose phosphoenolpyruvate phosphotransferase system., Mol Microbiol 54(4):1076-89

 [4] Vanderpool CK., Gottesman S., 2007, The novel transcription factor SgrR coordinates the response to glucose-phosphate stress., J Bacteriol 189(6):2238-48


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