RegulonDB

TRANSCRIPTION FACTOR:

Name:

ArgR	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Sensing external and internal signals

Synonym(s):

DNA-binding transcriptional dual regulator ArgR, XerA

Gene name(s):

argR

Functional conformation(s):

ArgR , ArgR-L-arginine

Coregulator(s):

AdiY, ArgR, CRP, DksA-ppGpp, FNR, Fur, GadE, H-NS, HdfR, IHF, Lrp, Nac, NtrC, PhoP, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Name:

NtrC	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

External-Two-component systems

Synonym(s):

DNA-binding transcriptional dual regulator NtrC, GlnG, GlnT, NtrC response regulator

Gene name(s):

glnG

Functional conformation(s):

NtrC-phosphorylated

Coregulator(s):

ArcA, ArgR, CRP, CysB, FNR, Fis, Fur, GadX, GlrR, IHF, Nac, NtrC, PhoP, RcsB, RutR, ppGpp

REGULATION EXERTED BY ArgR,NtrC

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
ArgR activator NtrC activator
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
ArgR-L-arginine	activator	astCp2	astE , astB , astD , astA , astC	1832157	1832174	-121.5	attcacccacATCGCAAACGTATTCACTttatatgcac	[EME] [GEA]	[1] [2]
ArgR-L-arginine	activator	astCp2	astE , astB , astD , astA , astC	1832135	1832152	-99.5	ttcactttatATGCACTTTAAATGCATAtggtttggtt	[GEA]	[2]
ArgR-L-arginine	activator	astCp2	astE , astB , astD , astA , astC	1832114	1832131	-78.5	atgcatatggTTTGGTTATAACTCCTTGatttccagtt	[GEA]	[2]
ArgR-L-arginine	activator	astCp2	astE , astB , astD , astA , astC	1832083	1832100	-47.5	tccagttagcCTCCGCCGTTTATGCACTtttatcactg	[GEA]	[2]
NtrC-phosphorylated	activator	astCp2	astE , astB , astD , astA , astC	1832311	1832327	-275.0	gttgttaatgATGTCAACGATGGCGCAaaaaatgccc	[GEA]	[2]
NtrC-phosphorylated	activator	astCp2	astE , astB , astD , astA , astC	1832289	1832305	-253.0	gcgcaaaaaaTGCCCGCTTTTGGTGCGcgctgcgtca	[GEA]	[2]
NtrC-phosphorylated	activator	astCp2	astE , astB , astD , astA , astC	1832269	1832285	-233.0	tggtgcgcgcTGCGTCAGAATGGCGCAgtaatttcca	[GEA]	[2]

Evidence:	[EME] Expression microarray evidence [GEA] Gene expression analysis
Reference(s):	[1] Caldara M., et al., 2006 [2] Kiupakis AK., et al., 2002

Reference(s)
[1] Caldara M., Charlier D., Cunin R., 2006, The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation., Microbiology 152(Pt 11):3343-54
[2] Kiupakis AK., Reitzer L., 2002, ArgR-independent induction and ArgR-dependent superinduction of the astCADBE operon in Escherichia coli., J Bacteriol 184(11):2940-50