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CysB regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CysB Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator CysB, positive transcriptional regulator for cysteine regulon
Gene name(s): cysB
Functional conformation(s): CysB-O-acetyl-L-serine , CysB , CysB-N-acetyl-L-serine , CysB-Sulphide , CysB-Thiosulfate
Coregulator(s): ArcA, Cbl, CpxR, CysB, FNR, H-NS, IHF, NtrC, PhoP
Summary: TF Summary ...[more]

REGULATION EXERTED BY CysB Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CysB activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CysB-O-acetyl-L-serine activator cysDp cysC , cysN , cysD 2876432 2876473 -85.0 cggtgccttaAGCACTTTTTGATATTAGCTTTGCCAAATCGTTATTCCGTTAaggaactact    
CysB-O-acetyl-L-serine activator ygeHp10 ygeH 2991285 2991327 -573.5 cagaaacaatTGAAATATTCAATAATAGTGATGAATGGGCAAATCAACTAAAAcacgcattat   [1]
CysB-O-acetyl-L-serine activator yoaCp1 yoaC 1893800 1893842 -145.5 agatattactGTTGATGCTTCTGCTAATTCATTATTTATATTTATAATTTCAAttttatctat   [1]
CysB activator tcyJp tcyJ

Reference(s): [1] Kawano Y., et al., 2015



Reference(s)    

 [1] Kawano Y., Ohtsu I., Takumi K., Tamakoshi A., Nonaka G., Funahashi E., Ihara M., Takagi H., 2015, Enhancement of L-cysteine production by disruption of yciW in Escherichia coli., J Biosci Bioeng 119(2):176-9

 [2] Chonoles Imlay KR., Korshunov S., Imlay JA., 2015, Physiological Roles and Adverse Effects of the Two Cystine Importers of Escherichia coli., J Bacteriol 197(23):3629-44

 [3] Liu H., Hou Y., Wang Y., Li Z., 2020, Enhancement of Sulfur Conversion Rate in the Production of l-Cysteine by Engineered Escherichia coli., J Agric Food Chem 68(1):250-257

 [4] Monroe RS., Ostrowski J., Hryniewicz MM., Kredich NM., 1990, In vitro interactions of CysB protein with the cysK and cysJIH promoter regions of Salmonella typhimurium., J Bacteriol 172(12):6919-29

 [5] Jovanovic M., Lilic M., Savic DJ., Jovanovic G., 2003, The LysR-type transcriptional regulator CysB controls the repression of hslJ transcription in Escherichia coli., Microbiology 149(Pt 12):3449-59

 [6] Lilic M., Jovanovic M., Jovanovic G., Savic DJ., 2003, Identification of the CysB-regulated gene, hslJ, related to the Escherichia coli novobiocin resistance phenotype., FEMS Microbiol Lett 224(2):239-46


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