RegulonDB

TRANSCRIPTION FACTOR:

Name:

NhaR	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

External sensing using transported metabolites

Synonym(s):

AntO, DNA-binding transcriptional activator NhaR, YaaB

Gene name(s):

nhaR

Functional conformation(s):

NhaR , NhaR-Na⁺

Coregulator(s):

H-NS, Lrp, NhaR, OmpR, RcsB

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

OmpR	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

External-Two-component systems

Synonym(s):

Cry, DNA-binding transcriptional dual regulator OmpR, Kmt, OmpB, OmpR response regulator

Gene name(s):

ompR

Functional conformation(s):

OmpR , OmpR-phosphorylated

Coregulator(s):

AcrR, ArcA, BasR, BolA, BtsR, CRP, CadC, CpxR, Cra, CsgD, EnvY, FNR, FadR, Fis, FliZ, Fur, GadE-RcsB, GadX, H-NS, HU, HdfR, IHF, LeuO, LrhA, Lrp, MarA, MatA, MlrA, MprA, MqsA, NagC, NhaR, OmpR, PhoB, PhoP, QseB, RcdA, RcsAB, Rob, RstA, SoxS, YjjQ, ppGpp

REGULATION EXERTED BY NhaR,OmpR

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
NhaR activator OmpR repressor
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
NhaR-Na⁺	activator	pgaAp	pgaD , pgaC , pgaB , pgaA	1092578	1092594	-63.0	tcatcaggacTTTCGAAAAATCCGAAAtcatgcatcg	[GEA]	[1] [2]
NhaR-Na⁺	activator	pgaAp	pgaD , pgaC , pgaB , pgaA	1092556	1092572	-41.0	cgaaatcatgCATCGGAATTTACTGATttaattattt	[GEA]	[1] [2]
OmpR-phosphorylated	repressor	pgaAp	pgaD , pgaC , pgaB , pgaA	1092545	1092564	-31.5	tgcatcggaaTTTACTGATTTAATTATTTTaatcctaatt	[GEA]	[3]

Evidence:	[GEA] Gene expression analysis
Reference(s):	[1] Cerca N., et al., 2008 [2] Goller C., et al., 2006 [3] Oropeza R., et al., 2015

Reference(s)
[1] Cerca N., Jefferson KK., 2008, Effect of growth conditions on poly-N-acetylglucosamine expression and biofilm formation in Escherichia coli., FEMS Microbiol Lett 283(1):36-41
[2] Goller C., Wang X., Itoh Y., Romeo T., 2006, The cation-responsive protein NhaR of Escherichia coli activates pgaABCD transcription, required for production of the biofilm adhesin poly-beta-1,6-N-acetyl-D-glucosamine., J Bacteriol 188(23):8022-32
[3] Oropeza R., Salgado-Bravo R., Calva E., 2015, Deletion analysis of RcsC reveals a novel signalling pathway controlling poly-N-acetylglucosamine synthesis and biofilm formation in Escherichia coli., Microbiology 161(Pt 4):903-13