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CpxR,CysB regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CpxR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): CpxR response regulator, DNA-binding transcriptional dual regulator CpxR, YiiA
Gene name(s): cpxR
Functional conformation(s): CpxR-phosphorylated , CpxR
Coregulator(s): AcrR, BaeR, BasR, BolA, BtsR, CRP, CpxR, Cra, CsgD, CysB, EnvY, Fis, FliZ, Fur, GadE, H-NS, IHF, Lrp, MarA, MarR, MlrA, MqsA, NsrR, OmpR, PdhR, PhoB, RcdA, RcsAB, RcsB, Rob, RstA, SoxS, TyrR, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CysB Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator CysB, positive transcriptional regulator for cysteine regulon
Gene name(s): cysB
Functional conformation(s): CysB-O-acetyl-L-serine , CysB , CysB-N-acetyl-L-serine , CysB-Sulphide , CysB-Thiosulfate
Coregulator(s): ArcA, Cbl, CpxR, CysB, FNR, H-NS, IHF, NtrC, PhoP
Summary: TF Summary ...[more]

REGULATION EXERTED BY CpxR,CysB Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CpxR activator CysB activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CpxR-phosphorylated activator dgcZp dgcZ 1623912 1623929 -41.0 aacttcggatTTCTATGAAAATATTGACgtaattttgc [GEA] [1]
[2]
CysB-O-acetyl-L-serine activator dgcZp dgcZ 1624023 1624065 -164.5 tgggccattaGGGTATTGGGTTATGCTATTTGTCATCCTTTTATTTACGATAAtgcagaggta   [3]

Evidence: [GEA] Gene expression analysis
Reference(s): [1] Raivio TL., et al., 2013
[2] Yamamoto K., et al., 2006
[3] Kawano Y., et al., 2015



Reference(s)    

 [1] Raivio TL., Leblanc SK., Price NL., 2013, The Escherichia coli Cpx envelope stress response regulates genes of diverse function that impact antibiotic resistance and membrane integrity., J Bacteriol 195(12):2755-67

 [2] Yamamoto K., Ishihama A., 2006, Characterization of copper-inducible promoters regulated by CpxA/CpxR in Escherichia coli., Biosci Biotechnol Biochem 70(7):1688-95

 [3] Kawano Y., Ohtsu I., Takumi K., Tamakoshi A., Nonaka G., Funahashi E., Ihara M., Takagi H., 2015, Enhancement of L-cysteine production by disruption of yciW in Escherichia coli., J Biosci Bioeng 119(2):176-9

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