RegulonDB RegulonDB 11.0: Regulon Form
   
   


CueR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CueR      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): CopR, DNA-binding transcriptional dual regulator CueR, YbbI
Gene name(s): cueR
Functional conformation(s): CueR-Cu+ , CueR-Ag , CueR-Au
Coregulator(s): CueR, FNR
Summary: TF Summary ...[more]

REGULATION EXERTED BY CueR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CueR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CueR-Cu+ activator copAp copA 511427 511445 -25.0 aatttcttgaCCTTCCCCTTGCTGGAAGGtttaaccttt [GEA] [1]
[2]
[3]
[4]
[5]
CueR-Cu+ activator cueOp cueO 137011 137029 -25.0 tgcggcttgaCCTTCCCGTAAGGGGAAGGactatgctca [GEA] [2]
[4]
[5]

Evidence: [GEA] Gene expression analysis
Reference(s): [1] Fang C., et al., 2021
[2] Outten FW., et al., 2000
[3] Petersen C., et al., 2000
[4] Xu Z., et al., 2019
[5] Yamamoto K., et al., 2005



Reference(s)    

 [1] Fang C., Philips SJ., Wu X., Chen K., Shi J., Shen L., Xu J., Feng Y., O'Halloran TV., Zhang Y., 2021, CueR activates transcription through a DNA distortion mechanism., Nat Chem Biol 17(1):57-64

 [2] Outten FW., Outten CE., Hale J., O'Halloran TV., 2000, Transcriptional activation of an Escherichia coli copper efflux regulon by the chromosomal MerR homologue, cueR., J Biol Chem 275(40):31024-9

 [3] Petersen C., Moller LB., 2000, Control of copper homeostasis in Escherichia coli by a P-type ATPase, CopA, and a MerR-like transcriptional activator, CopR., Gene 261(2):289-98

 [4] Xu Z., Wang P., Wang H., Yu ZH., Au-Yeung HY., Hirayama T., Sun H., Yan A., 2019, Zinc excess increases cellular demand for iron and decreases tolerance to copper in Escherichia coli., J Biol Chem 294(45):16978-16991

 [5] Yamamoto K., Ishihama A., 2005, Transcriptional response of Escherichia coli to external copper., Mol Microbiol 56(1):215-27


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