RegulonDB

TRANSCRIPTION FACTOR:

Name:

Fis	Weight Matrix Tractordb tool

Connectivity class

Global Regulator

Sensing Class

TFs for DNA-bending

Synonym(s):

DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor

Gene name(s):

fis

Functional conformation(s):

Fis

Coregulator(s):

AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, MazE-MazF, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, RcsB-BglJ, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

Lrp	Weight Matrix Tractordb tool

Connectivity class

Global Regulator

Sensing Class

Sensing external and internal signals

Synonym(s):

AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA

Gene name(s):

lrp

Functional conformation(s):

Lrp , Lrp-L-leucine

Coregulator(s):

AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, QseB, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp

Summary:

TF Summary ...[more]

REGULATION EXERTED BY DksA,DksA-ppGpp,Fis,Lrp,ppGpp

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
DksA inhibition DksA-ppGpp inhibition Fis activator Lrp repressor ppGpp inhibition
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
Fis	activator	rrsAp1	rrsA , ileT , alaT , rrlA , rrfA	4035099	4035113	-133.0	gggagcaggtGGCGAATTTCGCCCGagaaatcgcc	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1]
Fis	activator	rrsAp1	rrsA , ileT , alaT , rrlA , rrfA	4035121	4035135	-111.0	ccgagaaatcGCCCATTTAACCGACaaaccgacgc	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1]
Fis	activator	rrsAp1	rrsA , ileT , alaT , rrlA , rrfA	4035141	4035155	-91.0	ccgacaaaccGACGCTGAAATAAGCataaagaata	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1]
Fis	activator	rrsAp1	rrsA , ileT , alaT , rrlA , rrfA	4035161	4035175	-71.0	taagcataaaGAATAAAAAATGCGCggtcagaaaa		[1]
Fis	activator	rrsEp1	rrsE , gltV , rrlE , rrfE	4207686	4207700	-170.0	tttcaatggtGATCACAATTTTGACtgtggttacc	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1]
Fis	activator	rrsEp1	rrsE , gltV , rrlE , rrfE	4207713	4207727	-143.0	tggttaccgtGGGCAAAATACAGAAattacattga	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1]
Fis	activator	rrsEp1	rrsE , gltV , rrlE , rrfE	4207739	4207753	-117.0	ttacattgatGATTGTGGATAACTCtgtgcgtaaa	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1]
Fis	activator	rrsEp1	rrsE , gltV , rrlE , rrfE	4207755	4207769	-101.0	ggataactctGTGCGTAAAAAGGTAtaaagcgggc	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1]
Fis	activator	rrsEp1	rrsE , gltV , rrlE , rrfE	4207784	4207798	-72.0	gcgggcttttGCTGGGGAATGCAGCagtcagtcat	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1]
Lrp-L-leucine	repressor	rrsAp1	rrsA , ileT , alaT , rrlA , rrfA	4035160	4035171	-73.0	ataagcataaAGAATAAAAAATgcgcggtcag		[2]
Lrp-L-leucine	repressor	rrsAp1	rrsA , ileT , alaT , rrlA , rrfA	4035180	4035191	-53.0	atgcgcggtcAGAAAATTATTTtaaatttcct		[2]
Lrp-L-leucine	repressor	rrsEp1	rrsE , gltV , rrlE , rrfE

Evidence:	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s):	[1] Hirvonen CA., et al., 2001 [2] Pul U., et al., 2005

Reference(s)
[1] Hirvonen CA., Ross W., Wozniak CE., Marasco E., Anthony JR., Aiyar SE., Newburn VH., Gourse RL., 2001, Contributions of UP elements and the transcription factor FIS to expression from the seven rrn P1 promoters in Escherichia coli., J Bacteriol 183(21):6305-14
[2] Pul U., Wurm R., Lux B., Meltzer M., Menzel A., Wagner R., 2005, LRP and H-NS--cooperative partners for transcription regulation at Escherichia coli rRNA promoters., Mol Microbiol 58(3):864-76