RegulonDB RegulonDB 11.1: Regulon Form
   
   


CusR,HprR,PhoB regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
PhoB Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator PhoB, PhoB response regulator, PhoT
Gene name(s): phoB
Functional conformation(s): PhoB , PhoB-phosphorylated
Coregulator(s): AlpA, ArgP, AscG, CRP, CpxR, CusR, EnvY, FNR, Fur, GadE, GadE-RcsB, GadW, GadX, H-NS, HprR, IHF, Nac, NsrR, OmpR, PhoB, PrpR, QseB, RcdA, RstA, RutR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CusR      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): CusR response regulator, DNA-binding transcriptional activator CusR, YlcA
Gene name(s): cusR
Functional conformation(s): CusR , CusR-phosphorylated
Coregulator(s): ArcA, CRP, Cra, CusR, FNR, Fis, Fur, GadE, HprR, PdhR, PhoB
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
HprR      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator HprR, YedW
Gene name(s): hprR
Functional conformation(s): HprR-phosphorylated , HprR
Coregulator(s): ArcA, CRP, Cra, CusR, FNR, Fis, Fur, GadE, HprR, PdhR, PhoB
Summary: TF Summary ...[more]

REGULATION EXERTED BY CusR,HprR,PhoB Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CusR activator HprR activator PhoB activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CusR-phosphorylated activator cusCp cusC , cusF , cusB , cusA 595512 595528 -53.5 tattggcaaaATGACAATTTTGTCATTtttctgtcac [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
[3]
[4]
CusR-phosphorylated activator cusRp cusS , cusR 595512 595528 -57.5 gtgacagaaaAATGACAAAATTGTCATtttgccaata [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[3]
[4]
PhoB-phosphorylated activator cusCp cusC , cusF , cusB , cusA 595510 595528 -54.0 cttattggcaAAATGACAATTTTGTCATTtttctgtcac [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [5]
PhoB-phosphorylated activator cusRp cusS , cusR 595510 595528 -57.0 gtgacagaaaAATGACAAAATTGTCATTTtgccaataag [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [5]
CusR-phosphorylated activator hiuHp hiuH 2038870 2038886 38.5 agcctggttcATTACAAAATTGTAATGctgctgtaag [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [6]
[2]
HprR-phosphorylated activator hiuHp hiuH 2038869 2038887 38.5 cagcctggttCATTACAAAATTGTAATGCtgctgtaagg [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [6]
[2]
HprR-phosphorylated activator cusRp cusS , cusR 595511 595529 -57.5 ggtgacagaaAAATGACAAAATTGTCATTttgccaataa   [6]
PhoB-phosphorylated activator hiuHp hiuH

Evidence: [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s): [1] Munson GP., et al., 2000
[2] Urano H., et al., 2017
[3] Xu Z., et al., 2019
[4] Yamamoto K., et al., 2005
[5] Yang C., et al., 2012
[6] Urano H., et al., 2015



Reference(s)    

 [1] Munson GP., Lam DL., Outten FW., O'Halloran TV., 2000, Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12., J Bacteriol 182(20):5864-71

 [2] Urano H., Yoshida M., Ogawa A., Yamamoto K., Ishihama A., Ogasawara H., 2017, Cross-regulation between two common ancestral response regulators, HprR and CusR, in Escherichia coli., Microbiology 163(2):243-252

 [3] Xu Z., Wang P., Wang H., Yu ZH., Au-Yeung HY., Hirayama T., Sun H., Yan A., 2019, Zinc excess increases cellular demand for iron and decreases tolerance to copper in Escherichia coli., J Biol Chem 294(45):16978-16991

 [4] Yamamoto K., Ishihama A., 2005, Transcriptional response of Escherichia coli to external copper., Mol Microbiol 56(1):215-27

 [5] Yang C., Huang TW., Wen SY., Chang CY., Tsai SF., Wu WF., Chang CH., 2012, Genome-wide PhoB binding and gene expression profiles reveal the hierarchical gene regulatory network of phosphate starvation in Escherichia coli., PLoS One 7(10):e47314

 [6] Urano H., Umezawa Y., Yamamoto K., Ishihama A., Ogasawara H., 2015, Cooperative regulation of the common target genes between H2O2-sensing YedVW and Cu2+-sensing CusSR in Escherichia coli., Microbiology 161(Pt 4):729-38

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