RegulonDB

TRANSCRIPTION FACTOR:

Name:

Lrp	Weight Matrix Tractordb tool

Connectivity class

Global Regulator

Sensing Class

Sensing external and internal signals

Synonym(s):

AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA

Gene name(s):

lrp

Functional conformation(s):

Lrp , Lrp-L-leucine

Coregulator(s):

AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, QseB, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

Ada	Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional dual regulator / DNA repair protein Ada

Gene name(s):

ada

Functional conformation(s):

Ada-Methylated , Ada

Coregulator(s):

Ada, AidB, Lrp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

AidB	Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

isovaleryl-CoA dehydrogenase and DNA-binding transcriptional repressor, putative acyl-CoA dehydrogenase AidB

Gene name(s):

aidB

Functional conformation(s):

AidB-isovaleryl-CoA

Coregulator(s):

Ada, AidB, Lrp

Summary:

TF Summary ...[more]

REGULATION EXERTED BY Ada,AidB,Lrp

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
Ada activator AidB repressor Lrp repressor
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
Ada	activator	aidBp1	aidB	4414182	4414206	-53.5	cgcattacatTGCTGGATAAGAATGTTTTAGCAATctctttctgt	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1] [2] [3]
AidB-isovaleryl-CoA	repressor	aidBp1	aidB	4414186	4414212	-48.0	ttacattgctGGATAAGAATGTTTTAGCAATCTCTTTctgtcatgaa	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[4]
Lrp	repressor	aidBp1	aidB

Evidence:	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s):	[1] Landini P., et al., 1995 [2] Landini P., et al., 1995 [3] Volkert MR., et al., 1994 [4] Rippa V., et al., 2010

Reference(s)
[1] Landini P., Volkert MR., 1995, RNA polymerase alpha subunit binding site in positively controlled promoters: a new model for RNA polymerase-promoter interaction and transcriptional activation in the Escherichia coli ada and aidB genes., EMBO J 14(17):4329-35
[2] Landini P., Volkert MR., 1995, Transcriptional activation of the Escherichia coli adaptive response gene aidB is mediated by binding of methylated Ada protein. Evidence for a new consensus sequence for Ada-binding sites., J Biol Chem 270(14):8285-9
[3] Volkert MR., Hajec LI., Matijasevic Z., Fang FC., Prince R., 1994, Induction of the Escherichia coli aidB gene under oxygen-limiting conditions requires a functional rpoS (katF) gene., J Bacteriol 176(24):7638-45
[4] Rippa V., Amoresano A., Esposito C., Landini P., Volkert M., Duilio A., 2010, Specific DNA binding and regulation of its own expression by the AidB protein in Escherichia coli., J Bacteriol 192(23):6136-42
[5] Landini P., Hajec LI., Nguyen LH., Burgess RR., Volkert MR., 1996, The leucine-responsive regulatory protein (Lrp) acts as a specific repressor for sigma s-dependent transcription of the Escherichia coli aidB gene., Mol Microbiol 20(5):947-55