RegulonDB RegulonDB 11.1: Regulon Form
   
   


ArcA,CRP,TreR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP , CRP-cyclic-AMP
Coregulator(s): AaeR, AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FrlR, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PlaR, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RspR, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
ArcA Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class External-Two-component systems
Synonym(s): ArcA response regulator, CpxC, DNA-binding transcriptional dual regulator ArcA, Dye, FexA, Msp, Seg, SfrA, dye resistance protein
Gene name(s): arcA
Functional conformation(s): ArcA-phosphorylated , ArcA
Coregulator(s): AdiY, AppY, ArcA, BetI, BtsR, CRP, CadC, CaiF, Cra, CusR, CysB, DcuR, DksA-ppGpp, DnaA, DpiA, FNR, FadR, Fis, FlhDC, Fur, GadE, GadE-RcsB, GadW, GadX, GatR, GlcC, GlpR, H-NS, HipB, HprR, HypT, IHF, IclR, IscR, LexA, LldR, Lrp, MarA, McbR, Mlc, ModE, MqsA, NarL, NarP, NsrR, NtrC, OmpR, PdhR, PhoP, PuuR, RcdA, RcsB, RhaS, Rob, RutR, SdiA, SlyA, SoxR, SoxS, TorR, TreR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
TreR      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional repressor TreR
Gene name(s): treR
Functional conformation(s): TreR , TreR-α,α-trehalose 6-phosphate , TreR-Trehalose , TreR-D-trehalose 6-phosphate
Coregulator(s): ArcA, CRP, TreR
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArcA,CRP,TreR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArcA activator CRP repressor CRP unknown TreR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
ArcA-phosphorylated activator treBp treC , treB 4466440 4466454 -237.0 ggcgagcgtcGGTAATACGCCGTTAatgaaattcc [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
CRP-cyclic-AMP repressor treBp treC , treB 4466188 4466209 12.0 tctgcagccaACCAAAAATGTCATCTGCCATGgggctttatg   [2]
CRP-cyclic-AMP unknown treBp treC , treB 4466260 4466281 -60.5 ctgaacgataAATTGTGATCTTCGCTGCGTTTcgggaacgtt [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [2]
[3]
TreR repressor treBp treC , treB 4466283 4466299 -81.0 ccctgtcctgATCGTTTCCTGAACGATaaattgtgat [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [4]
[2]
TreR repressor treBp treC , treB 4466250 4466266 -48.0 tgatcttcgcTGCGTTTCGGGAACGTTcccgttttta [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [4]
[2]

Evidence: [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s): [1] Liu X., et al., 2004
[2] Klein W., et al., 1995
[3] Zheng D., et al., 2004
[4] Horlacher R., et al., 1997



Reference(s)    

 [1] Liu X., De Wulf P., 2004, Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling., J Biol Chem 279(13):12588-97

 [2] Klein W., Horlacher R., Boos W., 1995, Molecular analysis of treB encoding the Escherichia coli enzyme II specific for trehalose., J Bacteriol 177(14):4043-52

 [3] Zheng D., Constantinidou C., Hobman JL., Minchin SD., 2004, Identification of the CRP regulon using in vitro and in vivo transcriptional profiling., Nucleic Acids Res 32(19):5874-93

 [4] Horlacher R., Boos W., 1997, Characterization of TreR, the major regulator of the Escherichia coli trehalose system., J Biol Chem 272(20):13026-32

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