RegulonDB RegulonDB 11.1: Regulon Form
   
   


Lrp,Nac regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Nac Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator Nac
Gene name(s): nac
Functional conformation(s): Nac
Coregulator(s): AdiY, ArgP, ArgR, AsnC, CRP, CytR, FNR, Fur, GadE, HdfR, IHF, Lrp, Nac, NsrR, NtrC, PhoB, PurR, QseB
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Lrp Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Sensing external and internal signals
Synonym(s): AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA
Gene name(s): lrp
Functional conformation(s): Lrp , Lrp-L-leucine
Coregulator(s): AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, QseB, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY Lrp,Nac Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
Lrp activator Nac repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
Nac repressor serAp1 serA 3058479 3058493 -30.0 gcaaacgttcATATTGCCGCAATATtattttttga [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
Nac repressor serAp1 serA 3058468 3058482 -19.0 tattgccgcaATATTATTTTTTGATatgttgaaag [EXP-IEP-GENE-EXPRESSION-ANALYSIS]
[EXP-IEP-RNA-SEQ] 		[2]
[1]
Lrp activator serAp1 serA

Evidence: [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
[EXP-IEP-RNA-SEQ] high throughput RNA-seq evidence
Reference(s): [1] Blauwkamp TA., et al., 2002
[2] Aquino P., et al., 2017



Reference(s)    

 [1] Blauwkamp TA., Ninfa AJ., 2002, Nac-mediated repression of the serA promoter of Escherichia coli., Mol Microbiol 45(2):351-63

 [2] Aquino P., Honda B., Jaini S., Lyubetskaya A., Hosur K., Chiu JG., Ekladious I., Hu D., Jin L., Sayeg MK., Stettner AI., Wang J., Wong BG., Wong WS., Alexander SL., Ba C., Bensussen SI., Bernstein DB., Braff D., Cha S., Cheng DI., Cho JH., Chou K., Chuang J., Gastler DE., Grasso DJ., Greifenberger JS., Guo C., Hawes AK., Israni DV., Jain SR., Kim J., Lei J., Li H., Li D., Li Q., Mancuso CP., Mao N., Masud SF., Meisel CL., Mi J., Nykyforchyn CS., Park M., Peterson HM., Ramirez AK., Reynolds DS., Rim NG., Saffie JC., Su H., Su WR., Su Y., Sun M., Thommes MM., Tu T., Varongchayakul N., Wagner TE., Weinberg BH., Yang R., Yaroslavsky A., Yoon C., Zhao Y., Zollinger AJ., Stringer AM., Foster JW., Wade J., Raman S., Broude N., Wong WW., Galagan JE., 2017, Coordinated regulation of acid resistance in Escherichia coli., BMC Syst Biol 11(1):1

 [3] Kroner GM., Wolfe MB., Freddolino PL., 2019, Escherichia coli Lrp Regulates One-Third of the Genome via Direct, Cooperative, and Indirect Routes., J Bacteriol 201(3)

 [4] Yang L., Lin RT., Newman EB., 2002, Structure of the Lrp-regulated serA promoter of Escherichia coli K-12., Mol Microbiol 43(2):323-33

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