RegulonDB

TRANSCRIPTION FACTOR:

Name:

H-NS	Tractordb tool

Connectivity class

Global Regulator

Sensing Class

TFs for DNA-bending

Synonym(s):

BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR

Gene name(s):

hns

Functional conformation(s):

H-NS

Coregulator(s):

AcrR, AdiY, ArcA, ArgP, ArgR, BasR, BolA, BtsR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CreB, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MalT, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsAB, RcsB, RcsB-BglJ, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

Lrp	Weight Matrix Tractordb tool

Connectivity class

Global Regulator

Sensing Class

Sensing external and internal signals

Synonym(s):

AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA

Gene name(s):

lrp

Functional conformation(s):

Lrp , Lrp-L-leucine

Coregulator(s):

AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, QseB, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

StpA	Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

DNA-binding transcriptional repressor StpA with RNA chaperone activity, H-NS-like DNA-binding transcriptional repressor with RNA chaperone activity, HnsB

Gene name(s):

stpA

Functional conformation(s):

StpA

Coregulator(s):

CRP, CreB, Fis, H-NS, LeuO, Lrp, MalT, RcsB-BglJ, SlyA, StpA

Summary:

TF Summary ...[more]

REGULATION EXERTED BY H-NS,Lrp,StpA

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
H-NS repressor Lrp activator StpA repressor
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
Lrp	activator	stpAp1	stpA	2799068	2799083	-539.0	gcattttcgcATAGCGTATATCGCTGgctatgacta	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] [EXP-IEP-RNA-SEQ]	[1] [2] [3] [4]
Lrp	activator	stpAp1	stpA	2799019	2799034	-490.0	aaatttttatTTAGTCAGTTTTTGTAgataaaatat	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] [EXP-IEP-RNA-SEQ]	[1] [2] [3] [4]
Lrp	activator	stpAp1	stpA	2798636	2798650	-107.0	aatatataatCTTGAAATTATTCTGagagtttcag	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] [EXP-IEP-RNA-SEQ]	[1] [3] [4]
StpA	repressor	stpAp1	stpA

Evidence:	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis [EXP-IEP-RNA-SEQ] high throughput RNA-seq evidence
Reference(s):	[1] Free A., et al., 1997 [2] Ihara K., et al., 2017 [3] Kroner GM., et al., 2019 [4] Sonden B., et al., 1996

Reference(s)
[1] Free A., Dorman CJ., 1997, The Escherichia coli stpA gene is transiently expressed during growth in rich medium and is induced in minimal medium and by stress conditions., J Bacteriol 179(3):909-18
[2] Ihara K., Sato K., Hori H., Makino Y., Shigenobu S., Ando T., Isogai E., Yoneyama H., 2017, Expression of the alaE gene is positively regulated by the global regulator Lrp in response to intracellular accumulation of l-alanine in Escherichia coli., J Biosci Bioeng 123(4):444-450
[3] Kroner GM., Wolfe MB., Freddolino PL., 2019, Escherichia coli Lrp Regulates One-Third of the Genome via Direct, Cooperative, and Indirect Routes., J Bacteriol 201(3)
[4] Sonden B., Uhlin BE., 1996, Coordinated and differential expression of histone-like proteins in Escherichia coli: regulation and function of the H-NS analog StpA., EMBO J 15(18):4970-80
[5] Gueune H., Durand MJ., Thouand G., DuBow MS., 2008, The ygaVP genes of Escherichia coli form a tributyltin-inducible operon., Appl Environ Microbiol 74(6):1954-8