RegulonDB

TRANSCRIPTION FACTOR:

Name:

H-NS	Tractordb tool

Connectivity class

Global Regulator

Sensing Class

TFs for DNA-bending

Synonym(s):

BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR

Gene name(s):

hns

Functional conformation(s):

H-NS

Coregulator(s):

AcrR, AdiY, ArcA, ArgP, ArgR, BasR, BolA, BtsR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CreB, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MalT, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsAB, RcsB, RcsB-BglJ, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

RcsB	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

External-Two-component systems

Synonym(s):

DNA-binding transcriptional activator RcsB, RcsB response regulator

Gene name(s):

rcsB

Functional conformation(s):

RcsB-phosphorylated , RcsB , RcsB-acetylated

Coregulator(s):

AdiY, ArcA, CRP, CadC, CpxR, EvgA, FNR, Fis, FliZ, GadE, GadE-RcsB, GadW, GadX, GlrR, H-NS, LeuO, LexA, Lrp, MarA, NagC, NarL, NarP, NhaR, NtrC, OmpR, PhoB, PhoP, RcsB, RcsB-BglJ, Rob, SdiA, StpA, TorR, UvrY, YdeO, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

NhaR	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

External sensing using transported metabolites

Synonym(s):

AntO, DNA-binding transcriptional activator NhaR, YaaB

Gene name(s):

nhaR

Functional conformation(s):

NhaR-Na⁺ , NhaR

Coregulator(s):

H-NS, Lrp, NhaR, OmpR, RcsB

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

Lrp	Weight Matrix Tractordb tool

Connectivity class

Global Regulator

Sensing Class

Sensing external and internal signals

Synonym(s):

AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA

Gene name(s):

lrp

Functional conformation(s):

Lrp , Lrp-L-leucine

Coregulator(s):

AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, QseB, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp

Summary:

TF Summary ...[more]

REGULATION EXERTED BY H-NS,Lrp,NhaR,RcsB

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
H-NS repressor Lrp repressor NhaR activator RcsB activator
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
RcsB-phosphorylated	activator	osmCp1	osmC	1556548	1556561	-41.5	cggattttatTCGGAATATCCTGCttatcctcgt	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1] [2]
Lrp	repressor	osmCp1	osmC	1556537	1556551	-52.0	aatattttcgCCGGATTTTATTCGGaatatcctgc	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[3]
NhaR-Na⁺	activator	osmCp1	osmC	1556546	1556563	-42.0	gccggattttATTCGGAATATCCTGCTTatcctcgtgc	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[4] [5]
H-NS	repressor	osmCp1	osmC

Evidence:	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s):	[1] Davalos-Garcia M., et al., 2001 [2] Francez-Charlot A., et al., 2005 [3] Bouvier J., et al., 1998 [4] Sturny R., et al., 2003 [5] Toesca I., et al., 2001

Reference(s)
[1] Davalos-Garcia M., Conter A., Toesca I., Gutierrez C., Cam K., 2001, Regulation of osmC gene expression by the two-component system rcsB-rcsC in Escherichia coli., J Bacteriol 183(20):5870-6
[2] Francez-Charlot A., Castanie-Cornet MP., Gutierrez C., Cam K., 2005, Osmotic regulation of the Escherichia coli bdm (biofilm-dependent modulation) gene by the RcsCDB His-Asp phosphorelay., J Bacteriol 187(11):3873-7
[3] Bouvier J., Gordia S., Kampmann G., Lange R., Hengge-Aronis R., Gutierrez C., 1998, Interplay between global regulators of Escherichia coli: effect of RpoS, Lrp and H-NS on transcription of the gene osmC., Mol Microbiol 28(5):971-80
[4] Sturny R., Cam K., Gutierrez C., Conter A., 2003, NhaR and RcsB independently regulate the osmCp1 promoter of Escherichia coli at overlapping regulatory sites., J Bacteriol 185(15):4298-304
[5] Toesca I., Perard C., Bouvier J., Gutierrez C., Conter A., 2001, The transcriptional activator NhaR is responsible for the osmotic induction of osmC(p1), a promoter of the stress-inducible gene osmC in Escherichia coli., Microbiology 147(Pt 10):2795-803