RegulonDB

TRANSCRIPTION FACTOR:

Name:

LrhA	Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

DNA-binding transcriptional dual regulator LrhA, GenR

Gene name(s):

lrhA

Functional conformation(s):

LrhA

Coregulator(s):

AcrR, CRP, FliZ, Fur, H-NS, HdfR, IHF, LeuO, LrhA, Lrp, MatA, OmpR, QseB, RcsAB, SlyA, YjjQ, ppGpp

Summary:

TF Summary ...[more]

REGULATION EXERTED BY LrhA

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
LrhA activator
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
LrhA	activator	leuOp3	leuO	84000	84091	-253.0	attatatgttTTGCGATTTTTTTTGATATTGATTTGGTGAATATTATTGATCAATTAATGTTAAGAATTAATGCATTAAATATATAAATTAATTATTAAATAagcacattta	[EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] [EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1]
LrhA	activator	leuOp1	leuO	84000	84091	-109.0	attatatgttTTGCGATTTTTTTTGATATTGATTTGGTGAATATTATTGATCAATTAATGTTAAGAATTAATGCATTAAATATATAAATTAATTATTAAATAagcacattta	[EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] [EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1]
LrhA	activator	lrhAp	lrhA

Evidence:	[EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] Binding of purified proteins [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s):	[1] Breddermann H., et al., 2017

Reference(s)
[1] Breddermann H., Schnetz K., 2017, Activation of leuO by LrhA in Escherichia coli., Mol Microbiol 104(4):664-676
[2] Lehnen D., Blumer C., Polen T., Wackwitz B., Wendisch VF., Unden G., 2002, LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli., Mol Microbiol 45(2):521-32