RegulonDB

TRANSCRIPTION FACTOR:

Name:

ArgP	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional dual regulator ArgP, IciA

Gene name(s):

argP

Functional conformation(s):

ArgP-L-arginine , ArgP-L-lysine , ArgP

Coregulator(s):

ArgP, CRP, DnaA, FNR, Fis, Fur, H-NS, Lrp, LysR, Nac, NrdR, PhoB, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

Lrp	Weight Matrix Tractordb tool

Connectivity class

Global Regulator

Sensing Class

Sensing external and internal signals

Synonym(s):

AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA

Gene name(s):

lrp

Functional conformation(s):

Lrp , Lrp-L-leucine

Coregulator(s):

AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, QseB, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp

Summary:

TF Summary ...[more]

REGULATION EXERTED BY ArgP,Lrp

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
ArgP activator Lrp activator
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
ArgP-L-arginine	activator	argOp	argO	3068860	3068879	-33.5	ccaattaataTTATCAATTTCCGCTAATAAcaatcccgcg	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1] [2] [3] [4] [5] [6]
Lrp-L-leucine	activator	argOp	argO	3068873	3068889	-44.5	tttctgattgCCAATTAATATTATCAAtttccgctaa		[6]
Lrp-L-leucine	activator	argOp	argO	3068894	3068910	-65.5	ctggcctctcTCTTATTAGTTTTTCTGattgccaatt		[6]
Lrp-L-leucine	activator	argOp	argO	3068918	3068934	-89.5	aacgctgaggCCAGATAATACTCTCTGgcctctctct	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[6]
ArgP	activator	lysPp	lysP	2248633	2248652	-82.5	gagattggctGCTTTACTTATAATCCCTGGgcgatcatga	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] [IC]	[3] [5] [7]
ArgP-L-arginine	activator	argOp	argO	3068880	3068900	-53.5	tcttattagtTTTTCTGATTGCCAATTAATAttatcaattt	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] [IC]	[2] [3] [4] [5] [6]
ArgP	activator	lysPp	lysP	2248613	2248632	-62.5	taatccctggGCGATCATGAAGGTGTCTTAtaaccgtgta	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] [IC]	[3] [5] [7]
Lrp	activator	lysPp	lysP

Evidence:	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis [IC] Inferred by curator
Reference(s):	[1] Bouvier J., et al., 2008 [2] Laishram RS., et al., 2007 [3] Marbaniang CN., et al., 2011 [4] Nandineni MR., et al., 2004 [5] Nguyen Le Minh P., et al., 2018 [6] Peeters E., et al., 2009 [7] Ruiz J., et al., 2011

Reference(s)
[1] Bouvier J., Stragier P., Morales V., Remy E., Gutierrez C., 2008, Lysine represses transcription of the Escherichia coli dapB gene by preventing its activation by the ArgP activator., J Bacteriol 190(15):5224-9
[2] Laishram RS., Gowrishankar J., 2007, Environmental regulation operating at the promoter clearance step of bacterial transcription., Genes Dev 21(10):1258-72
[3] Marbaniang CN., Gowrishankar J., 2011, Role of ArgP (IciA) in Lysine-Mediated Repression in Escherichia coli., J Bacteriol 193(21):5985-96
[4] Nandineni MR., Gowrishankar J., 2004, Evidence for an arginine exporter encoded by yggA (argO) that is regulated by the LysR-type transcriptional regulator ArgP in Escherichia coli., J Bacteriol 186(11):3539-46
[5] Nguyen Le Minh P., Velazquez Ruiz C., Vandermeeren S., Abwoyo P., Bervoets I., Charlier D., 2018, Differential protein-DNA contacts for activation and repression by ArgP, a LysR-type (LTTR) transcriptional regulator in Escherichia coli., Microbiol Res 206:141-158
[6] Peeters E., Nguyen Le Minh P., Foulquie-Moreno M., Charlier D., 2009, Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP., Mol Microbiol 74(6):1513-26
[7] Ruiz J., Haneburger I., Jung K., 2011, Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli., J Bacteriol 193(10):2536-48