RegulonDB RegulonDB 11.1: Regulon Form
   
   


CRP,IHF,PaaX,SlyA regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP , CRP-cyclic-AMP
Coregulator(s): AaeR, AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FrlR, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PlaR, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RspR, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
PaaX      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional repressor PaaX, YdbY
Gene name(s): paaX
Functional conformation(s): PaaX , PaaX-phenylacetyl-CoA
Coregulator(s): CRP, IHF, PaaX, SlyA
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
SlyA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator SlyA
Gene name(s): slyA
Functional conformation(s): SlyA
Coregulator(s): ArcA, CRP, DksA-ppGpp, FNR, Fis, Fur, H-NS, IHF, LeuO, LrhA, McbR, PaaX, PhoP, RcdA, SdiA, SlyA, StpA, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
IHF Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator IHF
Gene name(s): ihfB, ihfA
Functional conformation(s): IHF
Coregulator(s): AcrR, AdiY, ArcA, ArgR, AtoC, BasR, BolA, BtsR, CRP, Cbl, CpxR, Cra, CsgD, CysB, DksA, DksA-ppGpp, EnvY, FNR, FadR, FhlA, Fis, FlhDC, FliZ, Fur, GadE, GlcC, GlpR, GlrR, H-NS, HU, HdfR, HipAB, HipB, IHF, IclR, IscR, LrhA, Lrp, MarA, MatA, MlrA, MntR, ModE, MprA, MqsA, Nac, NagC, NanR, NarL, NarP, NorR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PepA, PhoB, PlaR, PspF, PurR, QseB, RcdA, RcsAB, Rob, RstA, RtcR, RutR, SlyA, SoxR, SoxS, SutR, TdcA, TdcR, TrpR, TyrR, UlaR, UvrY, YeiL, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,IHF,PaaX,SlyA Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator IHF activator PaaX repressor SlyA activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
IHF activator paaAp paaA , paaB , paaC , paaD , paaE , paaF , paaG , paaH , paaI , paaJ , paaK 1453744 1453756 -115.0 gcgatctgtaTAGCAACTGCGGAaaacattaat [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
CRP-cyclic-AMP activator paaAp paaA , paaB , paaC , paaD , paaE , paaF , paaG , paaH , paaI , paaJ , paaK 1453796 1453817 -58.5 tataaaaataGGGTGCGAAATCCGTCACAGTTcaaacataca [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
PaaX repressor paaAp paaA , paaB , paaC , paaD , paaE , paaF , paaG , paaH , paaI , paaJ , paaK 1453875 1453913 30.0 taaaacaatgTGATTCGTGTTTTTAATTAATTCACGAAAACTGGAATCGtaaaggtgat [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
SlyA activator paaAp paaA , paaB , paaC , paaD , paaE , paaF , paaG , paaH , paaI , paaJ , paaK 1453840 1453851 -19.5 atttgtgattTTACTTAACTATtgtgtaactt [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [3]
[4]
SlyA activator paaAp paaA , paaB , paaC , paaD , paaE , paaF , paaG , paaH , paaI , paaJ , paaK 1453682 1453693 -177.5 ttgctaatagTTAAATCGCGAAtcataaaaag [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [3]
[4]
SlyA activator paaAp paaA , paaB , paaC , paaD , paaE , paaF , paaG , paaH , paaI , paaJ , paaK 1453785 1453796 -74.5 aaataatgatTTATAAAAATAGggtgcgaaat [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [3]
[4]

Evidence: [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s): [1] Ferrandez A., et al., 2000
[2] Kim HS., et al., 2004
[3] Bartoli J., et al., 2020
[4] Curran TD., et al., 2017



Reference(s)    

 [1] Ferrandez A., Garcia JL., Diaz E., 2000, Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli., J Biol Chem 275(16):12214-22

 [2] Kim HS., Kang TS., Hyun JS., Kang HS., 2004, Regulation of penicillin G acylase gene expression in Escherichia coli by repressor PaaX and the cAMP-cAMP receptor protein complex., J Biol Chem 279(32):33253-62

 [3] Bartoli J., Viala JP., Bouveret E., 2020, SlyA Transcriptional Regulator Is Not Directly Affected by ppGpp Levels., Front Microbiol 11:1856

 [4] Curran TD., Abacha F., Hibberd SP., Rolfe MD., Lacey MM., Green J., 2017, Identification of new members of the Escherichia coli K-12 MG1655 SlyA regulon., Microbiology 163(3):400-409

RegulonDB