RegulonDB

TRANSCRIPTION FACTOR:

Name:

CRP	Weight Matrix Tractordb tool

Connectivity class

Global Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB

Gene name(s):

crp

Functional conformation(s):

CRP , CRP-cyclic-AMP

Coregulator(s):

AaeR, AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FrlR, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PlaR, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RspR, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YjjQ, ZraR, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

Mlc	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

DNA-binding transcriptional repressor Mlc, DgsA

Gene name(s):

mlc

Functional conformation(s):

Mlc-EIIGlC , Mlc

Coregulator(s):

ArcA, CRP, Cra, Fis, Lrp, Mlc, NagC, SoxS

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

Lrp	Weight Matrix Tractordb tool

Connectivity class

Global Regulator

Sensing Class

Sensing external and internal signals

Synonym(s):

AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA

Gene name(s):

lrp

Functional conformation(s):

Lrp , Lrp-L-leucine

Coregulator(s):

AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, QseB, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp

Summary:

TF Summary ...[more]

REGULATION EXERTED BY CRP,Lrp,Mlc

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
CRP activator Lrp activator Mlc repressor
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
CRP-cyclic-AMP	activator	malTp	malT	3552943	3552964	-70.5	aaagatttggAATTGTGACACAGTGCAAATTCagacacataa	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1] [2] [3] [4] [5]
Mlc	repressor	malTp	malT	3553024	3553046	12.0	ccttataaccATTAATTACGAAGCGCAAAAAAAataatatttc	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[2]
Lrp	activator	malTp	malT

Evidence:	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s):	[1] Chapon C., et al., 1983 [2] Decker K., et al., 1998 [3] Eichenberger P., et al., 1997 [4] Eichenberger P., et al., 1996 [5] Menendez M., et al., 1987

Reference(s)
[1] Chapon C., Kolb A., 1983, Action of CAP on the malT promoter in vitro., J Bacteriol 156(3):1135-43
[2] Decker K., Plumbridge J., Boos W., 1998, Negative transcriptional regulation of a positive regulator: the expression of malT, encoding the transcriptional activator of the maltose regulon of Escherichia coli, is negatively controlled by Mlc., Mol Microbiol 27(2):381-90
[3] Eichenberger P., Dethiollaz S., Buc H., Geiselmann J., 1997, Structural kinetics of transcription activation at the malT promoter of Escherichia coli by UV laser footprinting., Proc Natl Acad Sci U S A 94(17):9022-7
[4] Eichenberger P., Dethiollaz S., Fujita N., Ishihama A., Geiselmann J., 1996, Influence of the location of the cAMP receptor protein binding site on the geometry of a transcriptional activation complex in Escherichia coli., Biochemistry 35(48):15302-12
[5] Menendez M., Kolb A., Buc H., 1987, A new target for CRP action at the malT promoter., EMBO J 6(13):4227-34
[6] Tchetina E., Newman EB., 1995, Identification of Lrp-regulated genes by inverse PCR and sequencing: regulation of two mal operons of Escherichia coli by leucine-responsive regulatory protein., J Bacteriol 177(10):2679-83