RegulonDB RegulonDB 11.1: Regulon Form
   
   


HU,IHF,TrpR,TyrR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
TyrR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator TyrR
Gene name(s): tyrR
Functional conformation(s): TyrR , TyrR-L-phenylalanine , TyrR-L-tryptophan , TyrR-L-tyrosine
Coregulator(s): CpxR, Cra, HU, IHF, PgrR, SoxR, TrpR, TyrR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
TrpR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional repressor TrpR, RtrY
Gene name(s): trpR
Functional conformation(s): TrpR , TrpR-L-tryptophan
Coregulator(s): HU, IHF, TrpR, TyrR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
IHF Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator IHF
Gene name(s): ihfB, ihfA
Functional conformation(s): IHF
Coregulator(s): AcrR, AdiY, ArcA, ArgR, AtoC, BasR, BolA, BtsR, CRP, Cbl, CpxR, Cra, CsgD, CysB, DksA, DksA-ppGpp, EnvY, FNR, FadR, FhlA, Fis, FlhDC, FliZ, Fur, GadE, GlcC, GlpR, GlrR, H-NS, HU, HdfR, HipAB, HipB, IHF, IclR, IscR, LrhA, Lrp, MarA, MatA, MlrA, MntR, ModE, MprA, MqsA, Nac, NagC, NanR, NarL, NarP, NorR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PepA, PhoB, PlaR, PspF, PurR, QseB, RcdA, RcsAB, Rob, RstA, RtcR, RutR, SlyA, SoxR, SoxS, SutR, TdcA, TdcR, TrpR, TyrR, UlaR, UvrY, YeiL, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
HU      Tractordb tool
Connectivity class Local Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator HU, HUalpha;beta;
Gene name(s): hupB, hupA
Functional conformation(s): HU
Coregulator(s): AcrR, CRP, GalR, GalS, H-NS, HU, IHF, Lrp, MarA, OmpR, Rob, SoxS, TrpR, TyrR
Summary: TF Summary ...[more]

REGULATION EXERTED BY HU,IHF,TrpR,TyrR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
HU repressor IHF repressor TrpR repressor TyrR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
TyrR-L-tyrosine activator mtrp2 mtr 3305958 3305975 -106.5 ggtggtgatgCGTAATCATCGCTGAACAgcgaacacaa [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
[3]
TyrR-L-tyrosine activator mtrp2 mtr 3305928 3305945 -76.5 gaacacaatcTGTAAAATAATATATACAgccccgattt [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
[4]
[3]
TrpR-L-tryptophan repressor mtrp2 mtr 3305863 3305880 -11.5 ttgtactcgtGTACTGGTACAGTGCAATgcataacaac [EXP-IEP-GENE-EXPRESSION-ANALYSIS]
[EXP-IEP-MICROARRAY] 		[5]
[1]
[6]
[4]
TrpR-L-tryptophan repressor mtrp2 mtr 3305871 3305888 -19.5 tctgtcttttGTACTCGTGTACTGGTACagtgcaatgc [EXP-IEP-GENE-EXPRESSION-ANALYSIS]
[EXP-IEP-MICROARRAY] 		[5]
[1]
[6]
[4]
IHF repressor mtrp2 mtr

Evidence: [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
[EXP-IEP-MICROARRAY] high throughput expression microarray evidence
Reference(s): [1] Heatwole VM., et al., 1991
[2] Sarsero JP., et al., 1991
[3] Yang J., et al., 1997
[4] Sarsero JP., et al., 1991
[5] Cho BK., et al., 2011
[6] Jeeves M., et al., 1999



Reference(s)    

 [1] Heatwole VM., Somerville RL., 1991, The tryptophan-specific permease gene, mtr, is differentially regulated by the tryptophan and tyrosine repressors in Escherichia coli K-12., J Bacteriol 173(11):3601-4

 [2] Sarsero JP., Pittard AJ., 1991, Molecular analysis of the TyrR protein-mediated activation of mtr gene expression in Escherichia coli K-12., J Bacteriol 173(23):7701-4

 [3] Yang J., Murakami K., Camakaris H., Fujita N., Ishihama A., Pittard AJ., 1997, Amino acid residues in the alpha-subunit C-terminal domain of Escherichia coli RNA polymerase involved in activation of transcription from the mtr promoter., J Bacteriol 179(19):6187-91

 [4] Sarsero JP., Wookey PJ., Pittard AJ., 1991, Regulation of expression of the Escherichia coli K-12 mtr gene by TyrR protein and Trp repressor., J Bacteriol 173(13):4133-43

 [5] Cho BK., Federowicz S., Park YS., Zengler K., Palsson BO., 2011, Deciphering the transcriptional regulatory logic of amino acid metabolism., Nat Chem Biol 8(1):65-71

 [6] Jeeves M., Evans PD., Parslow RA., Jaseja M., Hyde EI., 1999, Studies of the Escherichia coli Trp repressor binding to its five operators and to variant operator sequences., Eur J Biochem 265(3):919-28

 [7] Yang J., Camakaris H., Pittard AJ., 1996, In vitro transcriptional analysis of TyrR-mediated activation of the mtr and tyrP+3 promoters of Escherichia coli., J Bacteriol 178(21):6389-93

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