RegulonDB RegulonDB 11.1: Regulon Form
   
   


AscG,CRP,PhoB,PrpR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP , CRP-cyclic-AMP
Coregulator(s): AaeR, AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FrlR, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PlaR, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RspR, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
PhoB Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator PhoB, PhoB response regulator, PhoT
Gene name(s): phoB
Functional conformation(s): PhoB , PhoB-phosphorylated
Coregulator(s): AlpA, ArgP, AscG, CRP, CpxR, CusR, EnvY, FNR, Fur, GadE, GadE-RcsB, GadW, GadX, H-NS, HprR, IHF, Nac, NsrR, OmpR, PhoB, PrpR, QseB, RcdA, RstA, RutR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
PrpR      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator PrpR, YahP
Gene name(s): prpR
Functional conformation(s): PrpR-(2S,3S)-2-methylcitrate , PrpR
Coregulator(s): AscG, CRP, Cra, PhoB, PrpR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
AscG      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): DNA-binding transcriptional repressor AscG, Sac
Gene name(s): ascG
Functional conformation(s): AscG
Coregulator(s): AscG, CRP, PhoB, PrpR
Summary: TF Summary ...[more]

REGULATION EXERTED BY AscG,CRP,PhoB,PrpR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
AscG repressor CRP activator PhoB repressor PrpR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cyclic-AMP activator prpRp prpR 348529 348551 -68.5 ctaatccgcaAATATGCGTTTCAGTTAACGTTTcaggcaatgt [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
PrpR-(2S,3S)-2-methylcitrate repressor prpRp prpR 348487 348510 -27.5 gtttcaccgcGTTTCATTGCAACAATTATGAAACaagactaaac [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [2]
AscG repressor prpRp prpR 348527 348533 -58.5 tttcagttaaCGTTTCAggcaatgttt [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
AscG repressor prpRp prpR 348515 348521 -46.5 tttcaggcaaTGTTTCAccgcgtttca [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
AscG repressor prpRp prpR 348505 348511 -36.5 tgtttcaccgCGTTTCAttgcaacaat [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
AscG repressor prpRp prpR 348498 348504 -29.5 ccgcgtttcaTTGCAACaattatgaaa [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
AscG repressor prpRp prpR 348487 348493 -18.5 tgcaacaattATGAAACaagactaaac [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
PrpR-(2S,3S)-2-methylcitrate repressor prpRp prpR 348521 348544 -61.5 gcaaatatgcGTTTCAGTTAACGTTTCAGGCAATgtttcaccgc    
PhoB-phosphorylated repressor prpRp prpR 348486 348504 -24.0 ccgcgtttcaTTGCAACAATTATGAAACAagactaaacc [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [3]

Evidence: [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s): [1] Ishida Y., et al., 2009
[2] Lee SK., et al., 2005
[3] Yang C., et al., 2012



Reference(s)    

 [1] Ishida Y., Kori A., Ishihama A., 2009, Participation of regulator AscG of the beta-glucoside utilization operon in regulation of the propionate catabolism operon., J Bacteriol 191(19):6136-44

 [2] Lee SK., Newman JD., Keasling JD., 2005, Catabolite repression of the propionate catabolic genes in Escherichia coli and Salmonella enterica: evidence for involvement of the cyclic AMP receptor protein., J Bacteriol 187(8):2793-800

 [3] Yang C., Huang TW., Wen SY., Chang CY., Tsai SF., Wu WF., Chang CH., 2012, Genome-wide PhoB binding and gene expression profiles reveal the hierarchical gene regulatory network of phosphate starvation in Escherichia coli., PLoS One 7(10):e47314

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