RegulonDB

TRANSCRIPTION FACTOR:

Name:

OxyR	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional dual regulator OxyR, MomR, Mor, bifunctional regulatory protein sensor for oxidative stress

Gene name(s):

oxyR

Functional conformation(s):

OxyR

Coregulator(s):

CRP, DksA, ExuR, FNR, Fis, Fur, H-NS, HypT, IHF, IscR, MarA, MetJ, MetR, MntR, NarL, NarP, NsrR, OxyR, PdhR, Rob, SoxS, UxuR, YdcI, Zur, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

Fur	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

External sensing using transported metabolites

Synonym(s):

DNA-binding transcriptional dual regulator Fur

Gene name(s):

fur

Functional conformation(s):

Fur-Fe²⁺ , Fur , Fur-Mn²⁺

Coregulator(s):

AcrR, AdiY, ArcA, ArgP, ArgR, CRP, CdaR, CpxR, Cra, CusR, EnvY, FNR, Fis, FliZ, Fur, GadE, GadX, H-NS, HdfR, HprR, HypT, IHF, IscR, LrhA, Lrp, MarA, MatA, MetR, MntR, ModE, MqsA, Nac, NagC, NarL, NfeR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PurR, QseB, RcnR, RcsAB, Rob, RstA, RutR, SlyA, SoxR, SoxS, YjjQ, Zur, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

MntR	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

DNA-binding transcriptional dual regulator MntR, YbiQ

Gene name(s):

mntR

Functional conformation(s):

MntR-Mn²⁺ , MntR-Cd²⁺

Coregulator(s):

Fis, Fur, H-NS, IHF, MntR, OxyR

Summary:

TF Summary ...[more]

REGULATION EXERTED BY Fur,MntR,OxyR

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
Fur repressor MntR repressor OxyR activator
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
OxyR	activator	mntHp	mntH	2512780	2512796	-54.0	ctatcagagaAATCACCACAATCCATTtaaatgaatt	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1] [2]
MntR-Mn²⁺	repressor	mntHp	mntH	2512719	2512740	5.5	gcatagcatgAAACATAGCAAAGGCTATGTTTtagaggcaca	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[2] [3]
Fur-Fe²⁺	repressor	mntHp	mntH	2512757	2512775	-31.5	tccatttaaaTGAATTTGATAATCATTCTcgtttggcat	[EXP-IGI]	[2] [3]
OxyR	activator	mntHp	mntH	2512802	2512818	-76.0	ttttcgtagtCATAATCCTGGTCTATCagagaaatca	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] [EXP-IEP-RNA-SEQ]	[1] [2] [4]

Evidence:	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis [EXP-IGI] Inferred from genetic interaction [EXP-IEP-RNA-SEQ] high throughput RNA-seq evidence
Reference(s):	[1] Anjem A., et al., 2009 [2] Kehres DG., et al., 2002 [3] Patzer SI., et al., 2001 [4] Seo SW., et al., 2015

Reference(s)
[1] Anjem A., Varghese S., Imlay JA., 2009, Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli., Mol Microbiol 72(4):844-58
[2] Kehres DG., Janakiraman A., Slauch JM., Maguire ME., 2002, Regulation of Salmonella enterica serovar Typhimurium mntH transcription by H(2)O(2), Fe(2+), and Mn(2+)., J Bacteriol 184(12):3151-8
[3] Patzer SI., Hantke K., 2001, Dual repression by Fe(2+)-Fur and Mn(2+)-MntR of the mntH gene, encoding an NRAMP-like Mn(2+) transporter in Escherichia coli., J Bacteriol 183(16):4806-13
[4] Seo SW., Kim D., Szubin R., Palsson BO., 2015, Genome-wide Reconstruction of OxyR and SoxRS Transcriptional Regulatory Networks under Oxidative Stress in Escherichia coli K-12 MG1655., Cell Rep 12(8):1289-99