RegulonDB

TRANSCRIPTION FACTOR:

Name:

H-NS	Tractordb tool

Connectivity class

Global Regulator

Sensing Class

TFs for DNA-bending

Synonym(s):

BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR

Gene name(s):

hns

Functional conformation(s):

H-NS

Coregulator(s):

AcrR, AdiY, ArcA, ArgP, ArgR, BasR, BolA, BtsR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CreB, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MalT, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsAB, RcsB, RcsB-BglJ, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

LrhA	Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

DNA-binding transcriptional dual regulator LrhA, GenR

Gene name(s):

lrhA

Functional conformation(s):

LrhA

Coregulator(s):

AcrR, CRP, FliZ, Fur, H-NS, HdfR, IHF, LeuO, LrhA, Lrp, MatA, OmpR, QseB, RcsAB, SlyA, YjjQ, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

SlyA	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

DNA-binding transcriptional dual regulator SlyA

Gene name(s):

slyA

Functional conformation(s):

SlyA

Coregulator(s):

ArcA, CRP, DksA-ppGpp, FNR, Fis, Fur, H-NS, IHF, LeuO, LrhA, McbR, PaaX, PhoP, RcdA, SdiA, SlyA, StpA, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

LeuO	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional dual regulator LeuO

Gene name(s):

leuO

Functional conformation(s):

LeuO

Coregulator(s):

CRP, CadC, DksA-ppGpp, FNR, Fis, H-NS, LeuO, LrhA, MlrA, OmpR, RcsB-BglJ, SlyA, StpA, ppGpp

Summary:

TF Summary ...[more]

REGULATION EXERTED BY H-NS,LeuO,LrhA,SlyA,ppGpp

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
H-NS repressor LeuO activator LrhA activator SlyA activator ppGpp activation
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
H-NS	repressor	leuOp	leuO	84085	84099	-96.0	aaattaattaTTAAATAAGCACATTtaatccattt	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1] [2]
LeuO	activator	leuOp	leuO	84122	84142	-56.0	tagatgattgAGTATTCGCGGTAGTTATGATtagattgttt	[EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [IC]	[1] [2]
LrhA	activator	leuOp	leuO	84000	84091	-143.0	attatatgttTTGCGATTTTTTTTGATATTGATTTGGTGAATATTATTGATCAATTAATGTTAAGAATTAATGCATTAAATATATAAATTAATTATTAAATAagcacattta	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[3]
SlyA	activator	leuOp	leuO	84065	84076	-117.5	aattaatgcaTTAAATATATAAattaattatt	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[4]
SlyA	activator	leuOp	leuO	84057	84068	-125.5	atgttaagaaTTAATGCATTAAatatataaat	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[4]

Evidence:	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] Binding of purified proteins [IC] Inferred by curator
Reference(s):	[1] Chen CC., et al., 2005 [2] Stratmann T., et al., 2012 [3] Breddermann H., et al., 2017 [4] Curran TD., et al., 2017

Reference(s)
[1] Chen CC., Chou MY., Huang CH., Majumder A., Wu HY., 2005, A cis-spreading nucleoprotein filament is responsible for the gene silencing activity found in the promoter relay mechanism., J Biol Chem 280(6):5101-12
[2] Stratmann T., Pul U., Wurm R., Wagner R., Schnetz K., 2012, RcsB-BglJ activates the Escherichia coli leuO gene, encoding an H-NS antagonist and pleiotropic regulator of virulence determinants., Mol Microbiol 83(6):1109-23
[3] Breddermann H., Schnetz K., 2017, Activation of leuO by LrhA in Escherichia coli., Mol Microbiol 104(4):664-676
[4] Curran TD., Abacha F., Hibberd SP., Rolfe MD., Lacey MM., Green J., 2017, Identification of new members of the Escherichia coli K-12 MG1655 SlyA regulon., Microbiology 163(3):400-409