RegulonDB RegulonDB 11.1: Regulon Form
   
   


YefM,YefM-YoeB regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
YefM      Tractordb tool
Connectivity class Local Regulator
Synonym(s): YefM antitoxin of the YoeB-YefM toxin-antitoxin pair and DNA binding transcriptional repressor
Gene name(s): yefM
Functional conformation(s): YefM
Coregulator(s): YefM, YefM-YoeB
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
YefM-YoeB      Tractordb tool
Connectivity class Local Regulator
Synonym(s): YefM-YoeB antitoxin/toxin complex / DNA-binding transcriptional repressor, YefMB
Gene name(s): yefM, yoeB
Functional conformation(s): YefM-YoeB
Coregulator(s): YefM, YefM-YoeB
Summary: TF Summary ...[more]

REGULATION EXERTED BY YefM,YefM-YoeB Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
YefM repressor YefM-YoeB repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
YefM-YoeB repressor yefMp yoeB , yefM 2089737 2089750 -10.5 ttaacgctcaTCATTGTACAATGAactgtacaaa [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
YefM-YoeB repressor yefMp yoeB , yefM 2089725 2089738 2.5 attgtacaatGAACTGTACAAAAGaggagattga [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
YefM repressor yefMp yoeB , yefM 2089725 2089739 2.5 cattgtacaaTGAACTGTACAAAAGaggagattga [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
YefM repressor yefMp yoeB , yefM 2089737 2089751 -10.5 attaacgctcATCATTGTACAATGAactgtacaaa [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]

Evidence: [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s): [1] Kedzierska B., et al., 2007
[2] Kedzierska B., et al., 2020



Reference(s)    

 [1] Kedzierska B., Lian LY., Hayes F., 2007, Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB with paired DNA palindromes exerts transcriptional autorepression., Nucleic Acids Res 35(1):325-39

 [2] Kedzierska B., Potrykus K., Szalewska-Palasz A., Wodzikowska B., 2020, Insights into Transcriptional Repression of the Homologous Toxin-Antitoxin Cassettes yefM-yoeB and axe-txe., Int J Mol Sci 21(23)

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