RegulonDB

TRANSCRIPTION FACTOR:

Name:

LexA	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional repressor LexA, ExrA, Spr, Tsl, UmuA

Gene name(s):

lexA

Functional conformation(s):

LexA

Coregulator(s):

ArcA, CRP, DinJ-YafQ, DnaA, LexA, NagC, RcdA, RcsB-BglJ, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Name:

DinJ-YafQ

Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

DinJ-YafQ antitoxin/toxin complex / DNA-binding transcriptional repressor, DinJ/Q

Gene name(s):

yafQ, dinJ

Functional conformation(s):

DinJ-YafQ

Coregulator(s):

DinJ-YafQ, LexA

Summary:

TF Summary ...[more]

REGULATION EXERTED BY DinJ-YafQ,LexA

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
DinJ-YafQ repressor LexA repressor
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
LexA	repressor	dinJp	yafQ , dinJ	246517	246536	89.5	ctacaattcaAGCTGAATAAATATACAGCAcaggagatac	[EXP-IEP-GENE-EXPRESSION-ANALYSIS]	[1] [2]
DinJ-YafQ	repressor	dinJp	yafQ , dinJ	246519	246535	89.5	tacaattcaaGCTGAATAAATATACAGcacaggagat		[3]

Evidence:	[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s):	[1] Lewis LK., et al., 1994 [2] Ruangprasert A., et al., 2014 [3] Prysak MH., et al., 2009

Reference(s)
[1] Lewis LK., Harlow GR., Gregg-Jolly LA., Mount DW., 1994, Identification of high affinity binding sites for LexA which define new DNA damage-inducible genes in Escherichia coli., J Mol Biol 241(4):507-23
[2] Ruangprasert A., Maehigashi T., Miles SJ., Giridharan N., Liu JX., Dunham CM., 2014, Mechanisms of toxin inhibition and transcriptional repression by Escherichia coli DinJ-YafQ., J Biol Chem 289(30):20559-69
[3] Prysak MH., Mozdzierz CJ., Cook AM., Zhu L., Zhang Y., Inouye M., Woychik NA., 2009, Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage., Mol Microbiol 71(5):1071-87