RegulonDB RegulonDB 11.1: Regulon Form
   
   


Fis,NarL regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, MazE-MazF, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, RcsB-BglJ, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NarL Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator NarL, FrdR, NarR, nitrate/nitrite response regulator NarL
Gene name(s): narL
Functional conformation(s): NarL , NarL-phosphorylated
Coregulator(s): AppY, ArcA, CRP, Cra, DcuR, DpiA, EvgA, FNR, FhlA, Fis, FlhDC, Fur, H-NS, IHF, IscR, Lrp, ModE, NagC, NarL, NarP, NikR, NorR, NsrR, OxyR, PhoP, RcsB, RstA, SoxS, TorR, UvrY, YdeO
Summary: TF Summary ...[more]

REGULATION EXERTED BY Fis,NarL Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
Fis repressor NarL activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
NarL-phosphorylated activator ogtp ogt 1400322 1400329 -41.0 cttatcttttTGGTGGTAtggctgctga [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
NarL-phosphorylated activator ogtp ogt 1400331 1400338 -50.0 ccctatccacTTATCTTTttggtggtat [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
NarL-phosphorylated activator ogtp ogt 1400355 1400362 -74.0 ggtacttactATTCGTTAgtcttgccct [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
NarL-phosphorylated activator ogtp ogt 1400364 1400371 -83.0 gcgaaactggGTACTTACtattcgttag [EXP-IEP-GENE-EXPRESSION-ANALYSIS] [1]
[2]
Fis repressor ogtp ogt 1400359 1400373 -82.0 acgcgaaactGGGTACTTACTATTCgttagtcttg   [2]

Evidence: [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis
Reference(s): [1] Ruanto P., et al., 2020
[2] Squire DJ., et al., 2009



Reference(s)    

 [1] Ruanto P., Chismon DL., Hothersall J., Godfrey RE., Lee DJ., Busby SJW., Browning DF., 2020, Activation by NarL at the Escherichia coli ogt promoter., Biochem J 477(15):2807-2820

 [2] Squire DJ., Xu M., Cole JA., Busby SJ., Browning DF., 2009, Competition between NarL-dependent activation and Fis-dependent repression controls expression from the Escherichia coli yeaR and ogt promoters., Biochem J 420(2):249-57

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