RegulonDB evolutionary first Genes of Regulon

Summary of evolutionary conservation promoters regulated by ArgP

The evolutionary conservation of promoters is limited to Gammaproteobacteria and to sigma70 promoters. In general an promoter is conserved if, i) the position of the promoter from the gene start is conserved, or ii) the promoter sequence recognized by the sigma70 factor is conserved (p < 0.0001). To avoid redundancy, the orthologous regions were purged using the program Purge-Sequence from RSAtools. Orthologs consisted of BLAST reciprocal best hits using soft masking and Smith-Waterman alignments.

First gene Promoter name Evolutionary conservation ratio (nd) Footprint conservation
argO argOp 0.13
argP argPp (nd)
dapB dapBp1 0.04
dapBp2 0.15
dapD dapDp 0.13
dnaA dnaAp1 (nd)
dnaAp2 (nd)
gdhA gdhAp1 0.32
lysA lysAp 0.19
lysC lysCp1 0.03
lysCp2 0.03
lysP lysPp 0.15
nrdA nrdAp 0.32