RegulonDB RegulonDB 10.9: smallRNA Form
   

small regulatory RNA SdsN small RNA in Escherichia coli K-12 genome


Gene local context to scale (view description)

tcyN sdiA sdsN tcyL sdiAp1 sdiAp1 sdiAp1b sdiAp1b sdsNp sdsNp sdiAp2 sdiAp2 sdiAp2b sdiAp2b sdsNp2 sdsNp2 sdiAp3 sdiAp3 sdiAp4 sdiAp4 sdiAp6 sdiAp6
small RNA      
Gene name: sdsN    Texpresso search in the literature
Synonym(s): SdsN
Genome position: 1996921 --> 1997057
Strand: forward
Sequence: Get ribonucleotide sequence FastaFormat
GC content %:  
40.88
Note(s): The sdsN locus produces two small RNAs, SdsN137 and SdsN178, from different promoters. The smaller RNA, SdsN137, negatively regulates the synthesis of |FRAME: EG11261-MONOMER|, |FRAME: EG10456-MONOMER| and |FRAME: NARP-MONOMER NarP| and confers resistance to nitrofurans Hao Y,2016.
Due to its unusual interaction with Hfq, the larger product of the sdsN locus, SdsN178 does not regulate expression of NfsA or NarP. However, a shorter cleavage product of SdsN178, SdsN124, is able to repress expression of NfsA and HmpA Hao Y,2016.
This small RNA was first identified by RNA-Seq Raghavan R,2011.
Expression of sdsN is induced in stationary phase and is dependent on σS Hao Y,2016. During logarithmic growth in either LB or glucose minimal medium, approximately equal expression of an ~75 nt fragment has been detected 27190161.
SdsN: σS-dependent sRNA Hao Y,2016
Review: 32213244
Evidence: [IMP] Inferred from mutant phenotype
Reference(s): [1] Hao Y., et al., 2016
External database links:  
ECOCYC:
RNA0-361
M3D: small regulatory RNA SdsN


Regulation exerted by the small RNA    
  Target Mechanism Function Target Type Binding Site Evidence
Code
Reference(s)
LeftPos RightPos Sequence
 
hmp
nd
repressor
TU
2685841
2685846
GACGCU
[1]
 
nd
repressor
TU
2290501
2290508
UGCCUGAA
[1]
 
nd
repressor
Gene
891186
891192
GACGCCA
[1]
Evidence: [SM] Site mutation


Reference(s)    

 [1] Hao Y., Updegrove TB., Livingston NN., Storz G., 2016, Protection against deleterious nitrogen compounds: role of σS-dependent small RNAs encoded adjacent to sdiA., Nucleic Acids Res 44(14):6935-48


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