RegulonDB RegulonDB 11.2: smallRNA Form
   

Rac prophage; small regulatory RNA antitoxin RalA small RNA in Escherichia coli K-12 genome


Gene local context to scale (view description)

recT xisR rcbA ralR ralA recE Rac prophage; antitoxin RalA terminator ralAp ralAp intRp4 intRp4
small RNA      
Gene name: ralA    Texpresso search in the literature
Synonym(s): RalA, RalA antitoxin of the RalRA toxin-antitoxin system
Genome position: 1413556 --> 1413734
Strand: forward
Sequence: Get ribonucleotide sequence FastaFormat
GC content %:  
 36.87
Note(s): RalA acts as the antitoxin of a type I toxin-antitoxin system with RalR. RalA RNA base-pairs with the RalR mRNA, which may prevent translation of the RalR toxin. Antitoxin activity of RalA is dependent on |FRAME: CPLX0-1461 Hfq|, and Hfq binds directly to RalA Guo Y,2014.
In wild type cells, transcript levels of ralA are undetectable Guo Y,2014.
RalA: RalR antitoxin Guo Y,2014
Review: 32213244
Evidence: [EXP-IMP] Inferred from mutant phenotype
Reference(s): [1] Guo Y., et al., 2014
External database links:  
ECOCYC:
 RNA0-385
M3D: Rac prophage; small regulatory RNA antitoxin RalA


Regulation exerted by the small RNA    
  Target Mechanism Function Target Type Binding Site Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) Reference(s)
LeftPos RightPos Sequence
 
nd
repressor
Gene
1413790
1413805
UGCUUCUUUUUCACUU
S
[1]
Evidence: [EXP-IMP-SITE-MUTATION] Site mutation


Reference(s)    

 [1] Guo Y., Quiroga C., Chen Q., McAnulty MJ., Benedik MJ., Wood TK., Wang X., 2014, RalR (a DNase) and RalA (a small RNA) form a type I toxin-antitoxin system in Escherichia coli., Nucleic Acids Res 42(10):6448-62

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